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is acid reflux dangerous yahoo dating

The condition isn't harmful, but it can be uncomfortable and may be embarrassing . There's no cure, but you can manage it by watching how. Acid reflux and GERD are unlikely to cause heart palpitations directly. Anyone experiencing heart palpitations along with other serious. Jigneshkumar Patel, MD from Medical Center of Trinity explains acid reflux and it difficult to swallow, and Barrett's esophagus, which is a serious change in the.

In a systematic review, Chen et al evaluated the safety and effectiveness of endoscopic procedures for GERD. Randomized controlled trials and non-randomized comparative studies with at least 10 patients in each study arm, and case series studies of at least 10 patients, were included.

Of the 3 procedures that were tested against sham controls Stretta procedure, Bard EndoCinch and Enteryxpatient outcomes in the treatment group were either as good as, or significantly better than, those of control patients in terms of heartburn symptoms, quality of life and medication usage. However, for the 2 procedures that were tested against laparoscopic fundoplication Stretta procedure and Bard EndoCinchoutcomes for patients in the endoscopic group were either as good as, or inferior to, those for the laparoscopic group.

The authors concluded that currently there is insufficient evidence to determine the safety and effectiveness of endoscopic procedures for GERD, especially in the long-term. The EsophyX System is designed to perform a transoral incisionless fundoplication procedure using to reconstruct a valve at the gastro-esophageal junction through transoral delivery of multiple fasteners. Cadiere et al reported on the outcome of a short-term, uncontrolled study of the EsophyX system for treating GERD.

Exclusion criteria included an irreducible hiatal hernia greater than 2 cm. The investigators reported that other adverse events were mild and transient. Transoral Incisionless Fundoplication and EsophyX: Transoral Incisionless Fundoplication TIF with EsophyX is inserted through the patient's mouth under visual guidance of an endoscope, the EsophyX device is purportedly used to construct a durable antireflux valve with SerosaFuse Fasteners and tighten the LES, supposedly reestablishing a barrier to reflux and restoring the competency of the gastroesophageal junction.

An assessment of endoluminal gastroplication for GERD by the National Institute for Clinical Excellence concluded that "[c]urrent evidence on the safety and efficacy of endoluminal gastroplication for gastro-oesophageal reflux disease GORD does not appear adequate for this procedure to be used without special arrangements for consent and for audit or research.

At follow-up, PPI usage was elicited and 2 validated questionnaires were administered measuring GERD health-related quality of life range of 0 to 50 and symptom severity range of 0 to In limited preliminary evaluation, the initial North American experience with endolumenal fundoplication using the EsophyX device is that it appears to be safe and provides moderate effectiveness in treating the symptoms of GERD.

Moreover, the authors stated that further studies comparing this technique with conventional medical and surgical therapies are necessary. The American Society of General Surgeons' position statement on "Natural orifice surgery and transoral incisionless fundoplication" ASGS, stated that "ASGS supports the continued development and refinement of this procedure as well as other appropriate natural orifice procedures performed by adequately trained general surgeon specialists".

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While the ASGS Board of Trustees issued a favorable position statement regarding transoral incisionless fundoplication TIF ; its recommendation does not appeared to be based from a full-fledged technology assessment of the procedure.

The drawbacks of this study were its retrospective nature symptom data at baseline were based on retrospective recall and short-term follow-up. Furthermore, the lack of pH measuring systems at the authors' institutions prevented these researchers from measuring esophageal acid exposure before and after TIF. Five patients were re-operated for failed laparoscopic fundoplication. The median age was 58 range of 20 to 81 years and body mass index BMI was Post-fundoplication side effects were not reported after TIF.

This was a small, retrospective study with short-term follow-up; its findings need to be validated by well-designed studies. In all, 35 patients completed 6-month follow-up; 21 There were 26 patients with complete month follow-up; 11 Larger number of fasteners deployed during TIF was predictive of positive outcome; pre-TIF ineffective esophageal motility and hiatal hernia raised the risk of recurrence of GERD symptoms, but were not significant from a prospective point of view.

The major drawback of this small study was its uncontrolled design.

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The authors stated that "[i]n light of these results and awaiting randomized controlled studies on larger series, the TIF procedure can at present be offered as a complement to medical therapy or an alternative to surgery only in selected patients with small or no hiatal hernia, who refuse surgery or do not want long-term PPI therapy, or are intolerant or partial responders to PPI".

A total of 34 patients with a confirmed diagnosis of GERD symptoms that were inadequately controlled by anti-secretory medications, and who where either dissatisfied with their current therapy or not willing to continue taking medication, underwent TIF using EsophyX at the authors' community-based hospital. Follow-up assessments were completed in 28 patients. Median age of the study group was 57 years range of 23 to 77BMI was Transoral incisionless fundoplication was performed following a standardized TIF-2 protocol and resulted in reducing hiatal hernia and restoring the natural anatomy of the gastroesophageal GE junction Hill grade I.

There were no post-operative complications. The authors are currently enrolling patients in a prospective, multi-center TIF Registry.

Svoboda et al stated that natural orifice transluminal surgery NOTES has been introduced in endoscopic surgery as a new system offering the advantage of a less invasive procedure. The aims of our study were to evaluate the safety and efficacy of this procedure and length of hospital stay. Patients indicated for surgery of GERD were randomly assigned ratio 2: For TIF, the Plicator method was initially used for 18 patients, but the company terminated production in without a follower.

During the last 2 years the EsophyX method was used for 16 patients. The effect of both procedures was sustained over 12 months. Moreover, they noted that longer follow-up is necessary to verify efficacy for more years. Zagol and Mikami evaluated transoral fundoplication devices for GERD that have been commercially available within the last 5 years. Both blinded and unblinded randomized studies were evaluated. These investigators reviewed the literature for evaluations of primary transoral endoluminal fundoplication devices which included EndoCinch, NDO Plicator, Esophyx, and Stretta.

Reviews of all studies with greater than 20 patients were evaluated to assess the efficacy and safety of transoral fundoplication devices.

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These endoluminal devices were primary matched against sham procedures. The EndoCinch and Stretta procedures were the only devices compared to laparoscopic fundoplication, the current standard for surgical management of GERD. Endoluminal treatment of GERD has been shown to be safe and effective in recent studies. The authors still believe more randomized prospective studies need to be carried out to determine if endoluminal therapies will be a durable option for patients with GERD.

Continuing research will further the advancement of endoluminal GERD procedures in the future. Also, Frazzoni et al concluded that in patients with refractory GERD, EsophyX fundoplication is significantly less effective than laparoscopic fundoplication in improving reflux parameters and accordingly, in inducing symptom remission.

These treatments are very new and are not as common as medicines or surgery to treat GERD. People receiving one of these treatments may be in a study to see how well it works. In the randomized controlled trial, the proportion of patients who stopped or decreased PPI use was significantly greater in the Stretta group than the control group at 6 months but it was not significant at 1 year. No significant differences in heartburn symptoms, quality of life, acid exposure, and esophagitis outcomes were found.

The majority of cohort studies found significant improvements in GERD symptoms, quality of life, and medication use. In a prospective, open-label, multi-center, single-arm study, Bell et al attempted to validate previously reported safety and symptomatic outcomes of TIF: Symptom improvement and objective outcomes of TIF were analyzed at 6-month follow-up.

One hundred TIF procedures were performed. No complications were reported. The authors concluded that TIF is safe and effective in multiple community-based settings in the treatment of medically refractory GERD, as demonstrated by an absence of complications, excellent symptom relief, and complete cessation of PPIs at 6-month follow-up. The main drawbacks of this study were its non-randomized nature and short-term follow-up.

Furthermore, TIF is not as effective in primary symptom response as traditional laparoscopic fundoplication. Of 79 patients previously reported at 1 year, 12 were lost to follow-up, and 1 died from an unrelated cause.

The remaining 66 patients were followed-up and analyzed mITT.

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Of 66 patients, 12 underwent revisional procedures, leaving 54 patients for PP analysis at a median of 3. No adverse events related to TIF were reported at 2- or 3-year follow-up.

The authors concluded that the clinical outcomes at 3 years following TIF, patient satisfaction, healing of erosive esophagitis, and cessation of PPI medication support long-term safety and durability of the TIF procedure for those with initial treatment success.

Moreover, they noted that although complete normalization of pH studies occurred in a minority of patients, successful cases showed long-term durability. Yew and Chuah discussed the past and present status of anti-reflux endoluminal therapy.

Currently, there are 3 commonly employed anti-reflux endoluminal procedures: EndoCinch plication requires further study and modification of technique before it can be recommended because of durability issues. Preliminary studies have shown promising reduction in symptoms and medication use but evidence concerning safety and long-term durability is still pending.

The safety issue with injection technique is the main concern as evident from the incidences of implant withdrawals after reported major adverse events.

Future research with cautious monitoring is required before any new implant material can be recommended for commercial application. Radiofrequency ablation therapy is regaining popularity in treating refractory symptoms despite PPI use due to improved efficacy, durability, and safety after years of refinement of protocol. Toomey et al undertook a case-controlled registry study of three cohorts of 20 patients undergoing TIF or laparoscopic Nissen or Toupet fundoplications from to controlling for age, body mass index, and preoperative DeMeester scores.

All patients were prospectively followed. Median data are reported. The investigators reported that patients undergoing TIF had significantly shorter operative times in minutes: The authors stated that, no matter the approach, patients reported dramatic and similar reduction in symptom frequency and severity e. Kim and colleagues noted that while acid suppression with PPIs remains the mainstay of treatment of GERD, some patients showed refractory response to PPIs, necessitating further intervention.

After increasing dosage of PPIs and other kinds of pharmacological intervention adopting prokinetics or others, variable endoscopic treatments were introduced for the treatment of these refractory cases. Implantation of reabsorbable or synthetic materials in the distal esophagus was tried in vain and is expelled from the market due to limited efficacy and serious complication.

The sham procedure consisted of upper GI endoscopy under general anaesthesia. Neither the patient nor the assessor was aware of the patients' group affiliation. The primary effectiveness end-point was the proportion of patients in clinical remission after 6-month follow-up. Likewise, the secondary outcome measures were all in favour of the TIF2 procedure.

The authors stated that no safety issues were raised. Limitations of this study included its small size and limited duration of follow-up. Testoni et al assessed the long-term effect of TIF 2. Fifty patients underwent TIF.

Three-year figure remained stable up to 6 years. Symptom scores off PPI were significantly lower at 6, 12, 24, and 36 months. This figure remained substantially unchanged at 12 and 24 months, too. This small, single-center study needs to be replicated in larger multi-center studies. Hunter et al performed a prospective, sham-controlled trial to determine if TF reduced troublesome regurgitation to a greater extent than PPIs in patients with GERD.

Those with at least troublesome regurgitation based on the Montreal definition on PPIs underwent barium swallow, esophagogastroduodenoscopy, hour esophageal pH monitoring off PPIsand high-resolution esophageal manometry analyses.

Patients were blinded to therapy during follow-up period and reassessed at 2, 12, and 26 weeks. At 6 months, patients underwent hour esophageal pH monitoring and esophagogastroduodenoscopy. Control of esophageal pH improved after TF mean 9. Subjects from both groups who completed the protocol had similar reductions in GERD symptom scores. Severe complications were rare 3 subjects receiving TF and 1 receiving the sham surgery.

Between June and August63 patients were randomized at 7 US community hospitals. Primary outcome was elimination of daily troublesome regurgitation or extraesophageal symptoms. A review by Lo and Mashimo noted that, "although these results seem promising, additional research raises the issue of poor efficacy and early treatment failure after TIF".

The authors noted that results of TIF have been "mixed" with a few cases requiring surgical intervention. The authors noted that there is also concern over damage to adjacent structures such as the vagal nerves during relatively blind endoscopic suturing. Witteman et al evaluated effectiveness of TIF compared with proton pump inhibition in a population consisting of GERD patients controlled with PPIs who opted for an endoscopic intervention over lifelong drug dependence.

Patients with chronic GERD were randomized 2: Primary outcome measure was GERD-related quality of life. Secondary outcome measures were esophageal acid exposure, number of reflux episodes, PPI usage, appearance of the gastro-esophageal valve, and healing of reflux esophagitis.

Cross-over for the PPI group was allowed after 6 months. A total of 60 patients TIF: All patients allocated for PPI treatment opted for crossover.

The authors concluded that although TIF resulted in an improved GERD-related quality of life and produced a short-term improvement of the anti-reflux barrier in a selected group of GERD patients, no long-term objective reflux control was achieved.

Two patients who underwent revisional procedures by year 3 were included in the final analysis. The mean Reflux Symptom Index score improved from All outcome measures remained stable between 1- 2- and 3-year follow-ups. Sami Trad noted TIF performed with the EsophyX device is a totally endoscopic procedure with the objectives to mechanically repair a defective gastro-esophageal valve and to reduce small hiatal hernias.

is acid reflux dangerous yahoo dating

The recent publication of randomized controlled trials RCTs and long-term follow-up data offers the opportunity to re-evaluate this treatment modality and its role in the management of patients with chronic gastro-esophageal reflux disease GERD. Randomized controlled trials have confirmed the ability of TIF to eliminate troublesome GERD symptoms, heal esophagitis, and improve distal esophageal acid exposure in appropriately selected patient populations.

These studies establish TIF's superiority to conventional medical therapy, especially in clinical scenarios where proton-pump inhibitors PPIs fail to provide complete symptom relief across the spectrum of classic and atypical GERD manifestations, including regurgitation and laryngopharyngeal reflux. Long-term data indicated sustained positive outcomes and durability up to 6 years after procedure.

These results were achieved with a low rate of serious adverse events and usually without introducing troublesome dysphagia, gas bloat, or flatulence. The authors concluded that based on the most recent data, TIF appeared to be a valuable treatment alternative for the management of appropriately selected patients with moderate-to-severe chronic GERD symptoms.

A total of 18 studies patients published between and were identified, including 5 RCTs and 13 prospective observational studies. The esophageal acid exposure time and acid reflux episodes after TIF were not significantly improved; PPIs usage increased with time and most of the patients resumed PPIs treatment at reduced dosage during the long-term follow-up.

The total satisfaction rate after TIF was about The incidence of severe adverse events consisting of gastro-intestinal GI perforation and bleeding was 2. The authors concluded that TIF is an alternative intervention in controlling GERD-related symptoms with comparable short-term patient satisfaction.

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Moreover, they stated that long-term results showed decreased effectiveness with time; patients often resume PPIs at reduced doses in the near future.

Stefanidis and colleagues stated that TIF using the EsophyX device has been shown to be effective and safe in patients with gastro-esophageal reflux disease GERD ; however, the subset of patients that would mostly benefit from this technique remains unknown. These researchers evaluated the long-term efficacy and safety of the TIF procedure in patients with a history of esophagitis or proven chronic GERD who have achieved symptom control with the administration of proton pump inhibitors PPIsbut did not wish to continue receiving medications for life.

Patients with eosphagitis C and D or those with large hiatal hernias greater than 2 cm in length were excluded. Heartburn was eliminated in 12 out of the 21 patients included Overall, 32 patients out of the 44 patients Furthermore, 6 more patients The authors concluded that creation of an esophagogastric fundoplication using the EsophyX device abolished reflux symptoms in It is a chronic, progressive disorder that presents most typically with heartburn and regurgitation and atypically with chest pain, dysphagia, chronic cough, globus, or sore throat.

The mainstay for diagnosis and characterization of the disorder is esophagoduodenoscopy EGDhigh-resolution esophageal manometry, and symptom-associated ambulatory esophageal pH impedance monitoring. Additional studies that can be useful in certain clinical presentations include gastric scintigraphy and oral contrast upper GI radiographic series.

Refractory GERD can be surgically managed with various techniques. In obese individuals, laparoscopic Roux-en-Y gastric bypass should be considered due to significant symptom improvement and lower incidence of recurrent symptoms with weight loss.

Otherwise, laparoscopic Nissen fundoplication is the preferred surgical technique for treatment of this disease with concomitant hiatal hernia repair when present for either procedure. The short-term risks associated with these procedures include esophageal or gastric injury, pneumothorax, wound infection, and dysphagia. Outcomes after surgical management of refractory GERD are highly dependent on adherence to strict surgical indications and appropriate patient-specific procedure selection.

Stretta System is an endoscopic radiofrequency RF energy delivery system that uses a special single-use catheter to deliver constant tissue temperature for collagen contraction, purportedly resulting in tissue shrinkage and tightening of the gastroesophageal junction. Precisely controlled RF energy is delivered to create lesions in the muscle of the LES and gastric cardia. The resorption of these lesions over the following weeks creates a tighter LES and a less compliant cardia.

The tighter valve is thought to provide significantly increased resistance to gastric reflux. The procedure takes approximately 1 hour or less. Patients undergoing the procedure can get back to normal activities the next day. Triadafilopoulos and Utley reported that temperature-controlled endoluminal radiofrequency energy delivery the Stretta procedure has been demonstrated in several studies to be safe and effective for the treatment of GERD and is a promising new technology for this chronic disorder.

The author concluded that these techniques should be used selectively until more data are available and until results are compared to the safe and highly effective medical therapies. This is in agreement with Koop who stated that a number of new endoscopic techniques for the treatment of GERD have been developed, but the future for these is unclear. Galmiche and des Varannes reviewed the literature on endoluminal therapies for GERD, and reached the following conclusions about the Stretta procedure: Although some surgeons propose use of the Stretta procedure for patients with severe, refractory, or complicated GERD, clinical studies of the Stretta procedure have excluded these patients.

Patients refractory to PPIs, those with hiatus hernia larger than 2 cm, those with severe esophagitis, as well as obese individuals, have usually been excluded from these trials". No studies have involved direct comparisons with other established medical or surgical therapies. Some concern has also been expressed about the potential impact of these procedures on definitive management of GERD.

For instance, it is possible that previous endoscopic therapy might complicate or reduce the effectiveness of subsequent procedures.

Some severe, although very rare, complications including perforations have been observed, especially during early experience with the Stretta procedure.

Studies have been short-term; the long-term effectiveness of the procedure is unknown. Studies of radiofrequency catheterization Stretta have largely been uncontrolled.

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The only controlled study Corley, of the Stretta procedure has been published in abstract form only, and has failed to confirm that the results of uncontrolled studies regarding significant reductions in acid exposure and symptom relief.

Gamiche and des Varannes concluded: Comparative studies of the cost-effectiveness of endoscopic therapy should include medical strategies such as intermittent or on-demand PPI therapy. Assessment of relevant outcome measures, including economic endpoints and long-term efficacy, are required before these novel approaches are used in routine practice.

Their effectiveness will need to be compared with that of established treatment forms. Clear indications for Stretta treatment are nil because of the paucity of controlled data available, the limited follow-up currently available on treated patients, and the confusing nature of the data that are available.

This opinion is in sharp disagreement with the FDA k summary statement on Stretta concluding that, "the risk-benefit profile of Stretta is substantially equivalent to that of fundoplication surgery.

None of the control patients could stop PPI. Health-related quality of life scores were not different between groups. No significant change in oesophageal acid exposure OAE was noted between baseline and 6-months after RF. No severe complication was reported. However, in a majority of patients, PPI therapy can not be completely stopped.

This was a small study with short-term follow-up.

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This is due to progressive damage to the esophagus, resulting in inflammation, ulceration and possible scarring with narrowing. In addition, these symptoms may be indicative of esophageal cancer. All of these symptoms merit seeing a doctor for further care. At that time, the individual should undergo an upper endoscopy to evaluate the source of the problem. Barrett's esophagus is a condition where the lining of the esophagus changes because of chronic inflammation, generally due to GERD.

In the setting of chronic acid exposure, the cellular structure of the lower esophageal lining changes to look more like the cells lining the intestine. Barrett's esophagus itself has no specific symptoms, but this change can increase the risk of esophageal adenocarcinoma a type of esophageal cancer. Barrett's esophagus can be readily detected during an upper endoscopy but must be confirmed by biopsies.

The intent is to diagnose this condition, treat it medically and follow it over time before cancer has a chance to develop. If biopsies detect dysplasia a precancerous change in tissuethen your doctor will recommend either close endoscopic surveillance doing endoscopies at regular intervals with biopsiesendoscopic therapy or surgery.

After treatment, the esophagus grows back a normal healthy lining. Your physician will determine which treatment option is best for you.